Description
The enigmatic receptor KIR2DL5.
KIR2DL5 is the least understood member of the KIR family. By sequence, KIR2DL5 is a hybrid of KIR3DL1 (see Vivian et al., Nature (2011) 479:401-5) and KIR2DL4 (see Moradi and Vivian J Biol Chem. (2015) 290(16): 10460–10471). Yet, KIR2LD5 has the properties of neither. This project will involve biophysical and functional characterisation of KIR2DL5. This is a an opportunity for the student to learn protein chemistry X-ray crystallography and SAXS. The function of KIR2DL5 will be probed by cellular assays.
Essential criteria:
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords
Immune receptors, Innate immunity, structural biology
School
Biomedicine Discovery Institute (School of Biomedical Sciences) » Biochemistry and Molecular Biology
Available options
Honours
Time commitment
Full-time
Physical location
Clayton