Description
Thin, flat, branched actin cytoskeleton filled membrane protrusions like the lamellipodia and membrane ruffles are utilized by cells for a plethora of processes. While actin filaments are helical, with the probability of branching in all directions, most cellular protrusions are 2-dimensional. This project will investigate how dynamic flat protrusions are initiated and sustained when arising out of an essentially flat membrane using a combination of advanced fluorescence microscopy, in vitro reconstitution technique and simulations and modelling.
Essential criteria:
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords
Biophysics, optogenetics, lattice light-sheet microscopy, Actin, ruffles, lamellipodia, reconstitution, simulation
School
Biomedicine Discovery Institute (School of Biomedical Sciences) » Anatomy and Developmental Biology
Available options
Honours
Joint PhD/Exchange Program
Time commitment
Full-time
Physical location
Monash Clayton Campus
Co-supervisors
Dr
Darius Koester
(External)
Dr
Richard Morris
(External)