Description
Bronchopulmonary dysplasia (BPD) is a severe lung disease that is the main cause of disability and death in premature infants. Recent studies suggest that blocking mediators of type 2 immunity may provide protection to the lungs. In this study, the student will use an established neonatal model of BPD where mice receive a high oxygen insult from birth for 14 days to mimic the environment in the neonatal intensive care unit. They will examine the susceptibility of mice lacking key cellular and molecular mediators of type 2 immunity. The student will use a combination of neonatal animal model studies, multiparameter flow cytometry, histopathology and lung disease quantitation techniques.
Essential criteria:
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords
neonatal lung disease, bronchopulmonary dysplasia, lung development, type 2 immunity, animal disease models
School
School of Translational Medicine » Immunology and Pathology
Available options
PhD/Doctorate
Masters by research
Masters by coursework
Time commitment
Full-time
Top-up scholarship funding available
No
Physical location
Alfred
Co-supervisors
Dr
Evelyn Tsantikos
Dr
Malcolm Starkey