Pulmonary hypertension in our smallest babies - determining the optimal treatment.

Pulmonary hypertension affects approximately 2 to 4 per 1000 live births globally, with an even higher incidence in growth-restricted newborns. Pulmonary hypertension poses a significant challenge to the newborns well-being, impacting their long-term health outcomes. By understanding the underlying mechanisms and developing potential interventions, we aim to pave the way for improved care and outcomes for these vulnerable infants. In this project we will investigate the intricate mechanisms of fetal development and discover how fetal growth restriction impacts pulmonary function. Using a cutting-edge preclinical model, our team aims to understand how chronic exposure to hypoxia in the uterus leads to fetal growth restriction and also increases the risk of other diseases such as pulmonary hypertension. As a student on this project, you'll learn invaluable skills in fetal surgery, delve into the realm of immunohistochemical and molecular techniques, and collaborate closely with a diverse team of experts including neonatologists and physiologists.