Description
the development of clinically relevant cancer models that recapitulate human cancer is key to both understanding biological mechanisms of cancer growth as well fine tuning therapeutic cancer treatments. In this project, the student will work with both human tissues and animal models to develop 3-dimensional organotypic culture of genetically defined cancer models. Using CRISPR and other technologies we will genetically manipulate these models, and assess the contribution of new targets in mediating cancer growth. See our recent paper (Dannappel M., Zhu D., et al. J. Clin. Inves. 2022).
Essential criteria:
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords
colon cancer, organoids, models
School
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research » Molecular and Translational Sciences
Available options
PhD/Doctorate
Masters by research
Honours
Time commitment
Full-time
Top-up scholarship funding available
Yes
Year 1:
$3000
Physical location
Monash Health Translation Precinct (Monash Medical Centre)
Co-supervisors
Dr
Marius Dannappel