Description
In celiac disease (CD), the T cell response to gliadin peptides derived from gluten in from wheat, barley and rye has been well characterised. Whilst some gliadin peptide antigens generate a T cell response that is highly restricted to that antigen, other gliadin antigens can elicit a response whereby the same T cell can recognise more than one antigen. This project will characterise how TCRs isolated from a panel of such cross-reactive T cells are able to recognise peptides with disparate sequences presented by HLA-DQ2, the major disease predisposing allele for CD.
Essential criteria:
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords
celiac disease, structural biology, Biochemistry & Molecular Biology
School
Biomedicine Discovery Institute (School of Biomedical Sciences) » Biochemistry and Molecular Biology
Available options
PhD/Doctorate
Honours
Time commitment
Full-time
Top-up scholarship funding available
No
Physical location
Biomedicine Discovery Institute
Co-supervisors
Prof
Jamie Rossjohn