Dissecting Inflammation and Immunity in Cardiovascular Disease

Immune cells play a critical and under appreciated role in the development and outcome of cardiovascular diseases (CVD). Focusing on the adaptive immune system (T & B cells), we aim to deeply characterise the immune landscape in CVD using state-of-the-art technologies, identify causal mechanisms of immune dysregulation and chronic inflammation and define their role in the development and outcome of CVD. In this research we assess the underlying immunology of CVD in human tissues and animal models of these disease using techniques such as: ● Flow Cytometry ● Cell Culture ● Immunofluorescent Microscopy ● Immunohistochemistry ● Intravital and Multiphoton Microscopy ● Bulk and Single Cell RNA Sequencing ● Bulk and Single Cell ATAC Sequencing There is the opportunity to pursue several avenues for research projects, including: ● Deep characterisation of adaptive immune responses in human and murine cardiovascular disease. ● Defining the role of sexual dimorphism in the immune response in health and cardiovascular disease. ● The role of conventional vs unconventional T cells in atherosclerosis and myocardial infarction. ● Modulating adaptive immunity for the treatment of cardiovascular disease.