How does plasminogen promote wound healing?

Our ability to recover from injury is crucial for survival. The mechanism by which plasminogen promotes wound healing is poorly understood. It is believed to be regulated by various cellular plasminogen receptors. This project will investigate how the interplay between distinct receptors and plasminogen leads to wound resolution. We will use techniques such as flow cytometry and confocal microscopy to dissect the role of plasminogen receptors in the cellular functions and proteomics to study cellular responses. We will apply biophysical and biochemical assays, such as X-ray crystallography, cryo electron microscopy, surface plasmon resonance and enzymatic assays, to map the precise protein-protein interactions (Law 2012, Wu 2019).