Investigating novel treatments for gestational hypertension

Gestational hypertension and pre-eclampsia are relatively common pregnancy complications that increase the risk of adverse outcomes for the mother and baby. High blood pressure during pregnancy is also associated with a 4-fold risk of cardiovascular disease for the mother, later in life. There are few appropriate treatments for gestational hypertension and for preeclampsia, delivery of the baby is often the only option and this may lead to complications of premature birth. We have identified a signalling pathway that can be targeted to improve vascular homeostasis. Our preliminary findings suggest that targeting this pathway may lower blood pressure in a pre-clinical model of gestational hypertension. The current project will use different molecules to understand the mechanisms by which this targeted therapy may be harnessed for treating gestational hypertension. The methodology used in this project includes in vitro models (i.e. cell culture, isolated tissue experiments) and pre-clinical in vivo models (i.e. blood pressure, echocardiography). To investigate the mechanisms underpinning effects, RNA and protein analysis will be performed and endocrinology analysis will be undertaken. This project could be tailored for short or long duration projects and individual preferences.