Proteomic characterisation of the venom from Malaysian venomous jellyfish

Jellyfish envenomation is a common cause of marine injuries worldwide including Malaysia. There had been several deadly cases of jellyfish envenomation reported in Malaysia that causes Irukandji-like syndrome i.e. profound anaphylactic shock and mortality [1]. Classes of jellyfish that pose threat to human include the box jellyfish (Chironex fleckeri), carybdeids and Portugese man o’ war (Physalis physalis). Proteomics information on the venomous proteins/molecules could provide an in-depth insights into the mechanism of toxicity and death caused by these jellyfish. This can also lead towards the development of efficient anti-venom. Additionally, the information can be a valuable resource for novel protein/peptides discovery with potential therapeutic applications [2]. To date, there are limited studies available on the venom proteomics from venomous jellyfish commonly found in Malaysian waters. Therefore, this project aims to identify and characterize proteins from the venom of commonly found venomous jellyfish in Malaysian coastal waters using chromatography techniques and tandem mass spectrometry (LC-MS/MS). References 1. Lippmann, J.M., et al., Fatal and Severe Box Jellyfish Stings, Including Irukandji Stings, in Malaysia, 2000–2010. Journal of Travel Medicine, 2011. 18(4): p. 275-281. 2. Lee, H., Y.C. Kwon, and E. Kim, Jellyfish Venom and Toxins: A Review, in Marine and Freshwater Toxins: Marine and Freshwater Toxins, P. Gopalakrishnakone, et al., Editors. 2014, Springer Netherlands: Dordrecht. p. 1-14.