Description
When mitochondria are unable to function properly, the proteome changes to re-establish homeostasis. In this project, we will investigate why some mitochondrial proteins change in abundance in response to mitochondrial dysfunction and the implications for cellular metabolism. This project will use cell culture, CRISPR/Cas9 gene editing, proteomics and metabolomics approaches to investigate how mitochondria adapt their metabolism when challenged.
Essential criteria:
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords
Mitochondria; Mitochondrial Disease; CRISPR; Proteomics; Metabolomics
School
Biomedicine Discovery Institute (School of Biomedical Sciences) » Biochemistry and Molecular Biology
Available options
PhD/Doctorate
Honours
Time commitment
Full-time
Top-up scholarship funding available
No
Physical location
Biomedicine Discovery Institute