Unlocking the Secrets of Cardiometabolic Diseases through Multi-Omic Integration

Global Health Challenge: Cardiometabolic diseases are the leading cause of mortality worldwide, encompassing a spectrum of conditions such as cardiovascular disease (CVD), type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), and chronic kidney disease. The root of these diseases often lies in the complex dysregulation of lipid metabolism, presenting a critical target for intervention. Innovative Approach: At the forefront of metabolomics research, the Metabolomics Laboratory at the Baker Heart and Diabetes Institute is pioneering the integration of lipidomics and genomics to revolutionize our understanding and treatment of cardiometabolic diseases. With our advanced lipid profiling methodology – capable of measuring over 800 lipid species from a mere droplet of blood – we've set the stage for breakthroughs in early detection and risk assessment for conditions like CVD, T2D, cancer, and Alzheimer’s disease. Research Objective: This project seeks to harness our extensive collection of over 50,000 clinically relevant human samples for multi-omic integration. By deploying sophisticated statistical models and bioinformatic tools, we will dissect the complex interactions between lipid metabolic pathways, genetic-, environmental-, and lifestyle-factors, identifying novel biomarkers and therapeutic targets that can revolutionize the management of cardiometabolic diseases. Your Role and Opportunities: As an integral member of our team, you will delve into bioinformatics and statistical modelling, working with clinical and population cohorts to elucidate the relationships between lipid metabolism and cardiometabolic diseases. This project offers a unique blend of bioinformatics and computational work, providing you with a comprehensive skill set in multi-omics research, data analysis, and bioinformatics — highly sought-after skills in both academia and industry. Why This Project? • Direct Impact: Your work will directly contribute to identifying new preventative and therapeutic avenues for cardiometabolic diseases. • Advanced Skill Acquisition: Immerse yourself in the forefront of multi-omic research, gaining invaluable experience in the latest technologies and methodologies. • Collaborative Excellence: Join a dynamic, multidisciplinary team at a world-class institution, with access to a broad network of international collaborators. • Visibility and Professional Growth: Participate in a project with high potential for significant publications and presentations, bolstering your academic and professional profile. Ideal Candidate: We are looking for forward-thinking and motivated Honours or PhD students who are eager to dive into the complexities of multi-omic integration and its applications in combating cardiometabolic diseases. If you are driven by innovation and the prospect of making a tangible difference in healthcare, we encourage you to apply.